{"id":1578,"date":"2022-08-29T23:10:22","date_gmt":"2022-08-30T02:10:22","guid":{"rendered":"https:\/\/www.opge.org\/portal\/?p=1578"},"modified":"2022-08-29T23:10:26","modified_gmt":"2022-08-30T02:10:26","slug":"covid-19-coronavirus-sars-cov-2-and-the-small-bowel","status":"publish","type":"post","link":"https:\/\/www.opge.org\/?p=1578&lang=en","title":{"rendered":"Covid-19, Coronavirus, SARS-CoV-2 and the small bowel"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Although SARS-CoV-2 may primarily enter the cells of the lungs, the small bowel may also be an important entry or interaction site\u2026<br><br>ABSTRACT \u2013 Although SARS-CoV-2 may primarily enter the cells of the lungs, the small bowel may also be an important entry or interaction site, as the enterocytes are rich in angiotensin converting enzyme (ACE)-2 receptors. The initial gastro- intestinal symptoms that appear early during the course of Covid-19 support this hypothesis. Furthermore, SARS- CoV virions are preferentially released apically and not at the basement of the airway cells. Thus, in the setting of a productive infection of conducting airway epithelia, the apically released SARS-CoV may be removed by mucocil- iary clearance and gain access to the GI tract via a luminal exposure. In addition, post-mortem studies of mice infected by SARS-CoV have demonstrated diffuse damage to the GI tract, with the small bowel showing signs of enterocyte desquamation, edema, small vessel dilation and lympho- cyte infiltration, as well as mesenteric nodes with severe hemorrhage and necrosis. Finally, the small bowel is rich in furin, a serine protease which can separate the S-spike of the coronavirus into two \u201cpinchers\u201d (S1 and 2).The sep- aration of the S-spike into S1 and S2 is essential for the attachment of the virion to both the ACE receptor and the cell membrane. In this special review, we describe the inter- action of SARS-CoV-2 with the cell and enterocyte and its potential clinical implications.<br><a href=\"https:\/\/www.opge.org\/sitio\/images\/documentos\/2020\/Covid_and_Small_Bowel_REED.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><br><strong>Download complete file<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although SARS-CoV-2 may primarily enter the cells of the lungs, the small bowel may also be an important entry or interaction site\u2026 ABSTRACT \u2013 Although SARS-CoV-2 may primarily enter the cells of the lungs, the small bowel may also be an important entry or interaction site, as the enterocytes are rich in angiotensin converting enzyme [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1576,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[71],"tags":[],"class_list":["post-1578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.opge.org\/index.php?rest_route=\/wp\/v2\/posts\/1578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.opge.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.opge.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.opge.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.opge.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1578"}],"version-history":[{"count":1,"href":"https:\/\/www.opge.org\/index.php?rest_route=\/wp\/v2\/posts\/1578\/revisions"}],"predecessor-version":[{"id":1579,"href":"https:\/\/www.opge.org\/index.php?rest_route=\/wp\/v2\/posts\/1578\/revisions\/1579"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.opge.org\/index.php?rest_route=\/wp\/v2\/media\/1576"}],"wp:attachment":[{"href":"https:\/\/www.opge.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.opge.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.opge.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}